Biological age tests: Should you get one?

[ad_1] Should you’ve heard of billionaire Bryan Johnson, you’ve possible encountered the phrase “bio age testing.” Johnson, the topic of the Netflix documentary Don’t Die, says he’s on a quest to attain the bottom doable “organic age” (often known as bio age).

He reportedly spends hundreds of thousands annually on anti-aging remedies—dozens of every day dietary supplements, weekly acid peels for his pores and skin, injections to spice up collagen manufacturing, hyperbaric oxygen remedy, and plasma infusions extracted from his 17-year-old son’s physique.

To find out what’s working, Johnson has undergone quite a few assessments to evaluate his bio age. Johnson says these assessments present his age is now 5.1 years youthful than when he launched into his anti-aging quest.

Apparently, he’s getting older in reverse.

Granted, not everybody’s shopping for it. A New York Instances exposé, for instance, claims Johnson’s organic age, in actuality, has elevated by 10 years.1

Nonetheless, Johnson’s “don’t die” campaign is gaining traction.

Bio age assessments are a frequent subject on fashionable podcasts by Peter Attia, Joe Rogan, and Andrew Huberman. Google “bio age testing” and also you’ll see dozens of adverts for mail-order blood or urine testing kits that declare to disclose your organic age, tempo of getting older, and extra. With costs tumbling into affordability, it’s pure to surprise…

Must you or your shopper join bio age testing?

In that case, which check is greatest? Simply as importantly, what must you do with the data?

On this story, you’ll be taught:

What's your bio age? Your organic age (bio age) refers to how your cells operate. It’s not essentially the identical as your chronological age, which refers back to the variety of candles in your birthday cake.

For instance, let’s say Chang, a 50-year-old man, works at a desk, spends his free time in entrance of the TV, lives in probably the most polluted metropolis on the earth, eats a sweet bar for lunch, and smokes. Then again, Jabari, a unique 50-year-old man, hits the health club a number of occasions per week, lives within the mountains, doesn’t smoke, relishes his 5 servings of veggies a day, meditates, and spends most evenings in his backyard.

Genetics apart, you’d be sensible to wager that Jabari’s bio age is youthful than Chang’s.

How do these assessments measure bio age? Bio age testing kits measure a number of organic markers of getting older, often known as biomarkers.

For instance, some assessments deal with the scale of your telomeres, the protecting caps on the ends of chromosomes. Others measure DNA methylation, a physiological course of that chemically alters DNA.

As soon as an organization isolates and measures these markers out of your blood or urine, it plugs the bio information right into a formulation that calculates your bio age.

Nonetheless, when you see a health care provider with any regularity, you’re possible already monitoring some biomarkers of getting older. For instance, biomarkers corresponding to blood stress, levels of cholesterol, and blood glucose might help predict your threat of future heart problems, a number one explanation for untimely demise.

What’s the purpose of biomarker testing? Biomarker testing might help you monitor your wellness proactively somewhat than ready for illness signs to look.

For some, it additionally serves as a motivator. Should you be taught you might have the bones of somebody 20 years older, this may occasionally provide the nudge you have to begin energy coaching persistently.

As well as, biomarkers present goal information, permitting you to trace and consider varied health-related actions quantitatively. By monitoring your blood stress, you would possibly be taught that constant train helps, however your late-afternoon vitality drink does the other.

5 FREE biomarker assessments You don’t need to be a billionaire (or perhaps a millionaire) to trace biomarkers of getting older.

On this part, we’ll cowl a number of massively underappreciated, scientifically validated assessments you need to use to realize perception into your bio age—for FREE.

Earlier than scientists developed high-tech blood-based bio age assessments, researchers used these free assessments to calculate the tempo of getting older within the individuals they studied.

FREE biomarker check #1: Get off the ground People who find themselves fitter and stronger are likely to dwell longer.2

That’s as a result of muscle groups do extra than simply transfer us round. Additionally they secrete anti-inflammatory substances, assist to control blood sugar, gradual mobile getting older, defend the liner of the arteries, and extra. All this helps scale back the chance of age-related ailments, corresponding to kind 2 diabetes, hypertension, and coronary heart illness, a phenomenon we discover in our article, The New Science of Muscle.

Associated to energy, your capacity to steadiness can also be key. Should you’re middle-aged or older and might’t stand on one foot for a minimum of 10 seconds, your threat of dying within the subsequent seven years is double that of somebody who can stand for longer, in response to a research of 1,700 individuals.3

The Sitting-Rising Check (SRT) is one approach to assess each energy and steadiness on the similar time.

Individuals with low scores on this check have the next threat of dying from heart problems, in response to a 12-year research of 4,200 adults between the ages of 46 and 75.4

▶ The way to measure it

Decrease your self to the ground together with your legs in a crisscross place. Then, together with your legs in the identical place, stand again up. As you stand, discover when you should use part of your physique—hand, shin, knee—as leverage.

To attain your self, begin with 10 factors. Then, for every physique half you used to face, deduct a degree. Subtract a half level when you grew to become unsteady or misplaced your steadiness.

Remember the fact that this (and different assessments) function a proxy on your health. A low rating signifies that your steadiness and coordination, muscle energy and energy, and mobility might all require some consideration.

FREE biomarker check #2: Squeeze a ball Just like the SRT check, your grip energy gives perception into your general health. If the muscle groups in your fingers are weak, the muscle groups all through your physique usually tend to be weak, too.

Poor grip energy may also predict future muscle weak spot. In a single research, individuals with a weak grip have been extra more likely to stroll slowly and be unable to rise from a chair, full rigorous house responsibilities, or climb a flight of steps 25 years later.5

Low grip energy has additionally been related to:6

Low bone mineral density Elevated threat of falls Poor dietary standing Despair Poor sleep, cognitive operate, and/or high quality of life Elevated threat of coronary heart illness, most cancers, and untimely mortality

In accordance with one research, grip energy was a greater indicator of longevity (or lack thereof) than blood stress.7

▶ The way to measure it

Seize a normal tennis ball, and squeeze as exhausting as you may, for so long as you may.

Should you can handle 15 to 30 seconds earlier than your grip fatigues, you’re doing advantageous. Ninety seconds places you nicely above common—something over 90 ranks you solidly within the upper-third percentile.

Should you’re beneath 15, take into account that this check can also be only one indicator of your general energy. (And squeezing balls to enhance grip energy with out coaching the remainder of your physique is unlikely to make vital enhancements in your general well being and health.)

A hand-held dynamometer—accessible to be used at most occupational therapists’ and a few gyms—may also check grip energy. (Should you’re prepared to shell out some money, you should buy your personal for someplace between $100 and $500.)

FREE biomarker check #3: Stand on one foot A capability to steadiness on one foot for an prolonged interval might help scale back your threat of falls, one of many main causes of injury-related demise amongst older adults.

As well as, many alternative bodily techniques—the eyes, inside ear, skeletal muscle groups, and mind—should work collectively that will help you keep upright.

Situations like diabetes, coronary heart illness, and most cancers can all have an effect on steadiness. Because of this, an lack of ability to face on one foot can function a warning signal for eroding well being and health.8

▶ The way to measure it

Stand close to a wall or chair for security. Hold your eyes open and fingers in your hips. Then, raise your dominant leg and begin timing your self. As soon as you set your foot down, cease the clock. Repeat the check together with your non-dominant leg.

After getting your occasions, examine them to the next averages, from a research out of Duke College, to see how you probably did in comparison with your age-matched friends.9

Age Seconds on one leg (males) Seconds on one leg (females)

30-39 59 56

40-49 56 55

50-59 42 48

60-69 40 38

70-79 27 25

80+ 13 11

FREE biomarker check #4: How you're feeling Typically you realize why you’re drained, such because the morning after binge-watching the previous few episodes of a thriller. When you atone for your sleep, the weariness lifts.

That’s not the identical factor as fatigue, which describes persistent exhaustion that worsens over time and interferes with life. Along with feeling bodily drained, somebody who’s fatigued feels mentally uninteresting and emotionally exhausted.

Consider fatigue as an early signal that one thing’s off, particularly when you don’t know the trigger.

Let’s say you’ve already dominated out the same old suspects like an excessive amount of caffeine, dehydration, an excessive amount of alcohol, treatment unwanted effects, power stress, or an excessive amount of or too little train. What’s left is probably going a sleep problem or a creating well being downside corresponding to anemia, weight problems, despair, most cancers, or diabetes, to call a couple of.

Should you’re 60 or older, fatiguability—or how worn out you're feeling after an exercise—may also predict longevity.

In accordance with analysis out of the College of Pittsburgh Medical Heart, the upper somebody scores in fatiguability, the upper their threat of demise sooner or later.10 Different analysis has linked excessive fatiguability with declines in gait pace, strolling capacity, and different assessments of health.11

▶ The way to measure it

To measure fatigability, use a software known as the Pittsburgh Fatigability Scale. Utilizing a 0 (no fatigue) to five (excessive fatigue) scale, fee how fatigued you assume you'd really feel after finishing the next actions:

Exercise Length Rating (0 to five)

Leisurely strolling half-hour

Brisk or quick strolling 1 hour

Mild family exercise 1 hour

Heavy gardening or yard work 1 hour

Watching tv 2 hours

Sitting quietly 1 hour

Reasonable-to-high depth energy coaching half-hour

Collaborating in a social exercise 1 hour

Internet hosting a social occasion for 60 minutes 1 hour

Excessive depth exercise half-hour

Add all scores:

Should you rating lower than 15, you’re doing nicely. Scores between 15 and 24 are a warning signal. Something 25 and above is considered extreme, and price mentioning to your healthcare skilled.12

FREE biomarker check #5: Physique composition Regardless of fashionable perception, each too little and an excessive amount of physique fats can affect well being for the more severe, as we discover in our infographic, Is physique fats good or dangerous for you?

An excessive amount of fats raises the chance for: Too little muscle raises threat for:

Coronary heart illness Coronary heart illness

Hypertension Hypertension

Most cancers Most cancers

Fatty liver illness Stroke

Insulin resistance Insulin resistance

Kind 2 diabetes Sooner mobile getting older

Irritation Irritation

Joint misery Despair and nervousness

Sleep apnea Falls and lack of steadiness

Your muscle mass additionally performs a job, which is why somebody’s physique composition issues greater than their weight.

The gold normal strategies that estimate physique composition—underwater weighing, air displacement (Bod Pod), and dual-energy X-ray absorptiometry (DEXA)—definitely aren’t free.

Nonetheless, a latest research decided {that a} good old school (and low-cost) tape measure can present a comparably correct estimate of physique composition.13

▶ The way to measure it

To make use of a tape measure to maintain observe of your physique fats share, measure:

The widest a part of your neck The narrowest a part of your waist (For some individuals, this shall be on the navel. For others, it could be barely above the navel) The widest a part of your hips

Make sure the tape is cosy however not so tight that it cuts into the pores and skin. After getting your measurements, plug these numbers—alongside together with your age, intercourse, peak, and weight—into our FREE Physique Fats Calculator, which can take it from there.

Physician-approved biomarker assessments Relying on the place you reside on the earth, the next assessments is probably not free. Nonetheless, as a part of routine preventative care, your insurance coverage would possibly cowl them.

Physician-approved check #1: Blood panel In case your main care physician recommends yearly blood work, it’s for good purpose.

By retaining tabs on a number of blood markers, you may see in case your well being is trending towards kind 2 diabetes or coronary heart illness, each main causes of untimely mortality.

Many blood markers will also be influenced comparatively rapidly (inside 6 to 12 weeks) via way of life adjustments, complement protocols, or medicines. This makes them sensible instruments for monitoring whether or not varied way of life or medical modifications are working.

▶ The way to measure it

Should you’re not already doing so, contemplate having the next blood markers examined yearly. Then, speak to your well being care skilled about what your numbers imply. They could use the next numbers, alongside together with your blood stress, to calculate a heart problems threat rating.

Blood marker Optimum vary

Complete ldl cholesterol < 200 mg/dL*

LDL < 100 mg/dL for these with out coronary heart illness< 70 mg/dL for these with a historical past of coronary heart assault or stroke

HDL > 60 mg/dL

Triglycerides < 150 mg/dL

Alipoprotein B (Apo B) < 133 mg/dL (males)< 117 mg/dL (females)

Lipoprotein (a) < 30 mg/dL

C-reactive protein < 2.0 mg/L**

Fasting glucose < 100 mg/dL

Hemoglobin A1C < 5.7%

*Milligrams per deciliter of blood**Milligrams per liter

Physician-approved check #2: Bone density When researchers research wholesome super-agers aged 90 and older, robust bones are one in every of their defining options.14

That could be as a result of, like muscle groups, bones are dwell organs that secrete substances that could be helpful to general well being and longevity.15

For instance, bones secrete osteocalcin, a hormone that performs a job in bone reworking. When osteocalcin circulates within the physique, it’s thought to play a job in all the pieces from serving to muscle groups to supply ATP to regulating mind neurotransmitters.

Due to these diverse roles, it’s thought that, as bones put on away, osteocalcin ranges drop, contributing to many age-related well being issues, together with diabetes, low muscle mass, and cognitive points.16 17 (Not less than, that’s the idea. Most of this analysis has been completed on mice.)

Osteocalcin apart, lack of bone density can, in fact, result in fractures, which may enhance your threat of demise for as much as 10 years after a break.18

It’s particularly necessary to maintain tabs on bone well being when you’re in any of those high-risk classes:

You’re feminine and went via menopause earlier than age 45. You’ve been sedentary most of your grownup life. You're taking medicines corresponding to diuretics or stomach-acid blockers, that are linked with an elevated threat of osteoporosis. You have got a historical past of nicotine use or extreme alcohol consumption. You have got a medical situation, corresponding to diabetes or thyroid illness, that raises your threat. You have got a household historical past of osteoporosis.

▶ The way to measure it

Twin-energy X-ray absorptiometry (DEXA) scans are a kind of X-ray that measures the quantity of bone mineral content material packed right into a sq. centimeter of bone.

Insurance coverage typically received’t cowl these scans for individuals youthful than 65 except there’s a documented threat of creating osteoporosis. Out of pocket, the typical value is about $300.

While you obtain your DEXA outcomes, you’ll see a T-score that represents how your bone density compares to the typical bone density of a younger grownup with peak bone mass. A T-score of +1.0 to -1.0 means you might have regular bone mineral density for somebody your age. Something beneath -1.0 means you might need osteopenia (low bone mineral density) or osteoporosis (porous bones which might be liable to fracture).

Business bio age assessments You probably have some cash to burn, you may be taught an terrible lot about your physique.

Right here, you’ll discover a fast run-down on a few of the extra high-tech assessments you will get and what they'll inform you.

Nonetheless, earlier than we get into the small print, we wish to level out a couple of caveats:

▶ Organic age can range over time, and by organ. Somebody might undergo a interval of accelerated getting older—saying, throughout a interval of intense stress—then their fee of getting older might gradual as they focus extra on restoration. Moreover, organs can age at totally different charges. For instance, somebody with coronary heart illness might have a comparatively older coronary heart than their kidneys. (Not all assessments measure particular person organ age, but it surely’s changing into extra frequent.)

▶ Business assessments received’t at all times precisely mirror the adjustments you’re making. Till extra analysis helps the reliability of those assessments, consider your behaviors over remoted check outcomes. Should you’re consuming extra fruits and veggies, exercising extra persistently, managing stress, and in any other case slaying the wholesome way of life division, don’t sweat your outcomes. Deal with doing the issues we all know enhance well being.

▶ If an organization pairs your check outcomes with a tough promote for a proprietary and costly complement protocol, be cautious. It’s higher to share and talk about your outcomes with a trusted well being skilled than take well being recommendation from a profit-seeking stranger over the web.

Business check #1: DNA methylation DNA methylation is a organic course of that chemically alters DNA. As a result of the speed of methylation accelerates with getting older, it may be used to estimate somebody’s organic age and life expectancy, finds analysis.19 20 21

The Horvath Clock and DunedinPACE each measure particular biomarkers that can be utilized to higher perceive somebody’s methylation fee. Scientists developed these assessments to assist different scientists research how varied way of life components, environmental exposures, and medicines have an effect on getting older. They didn’t develop the assessments as a method for the typical individual to pinpoint their organic age. (Which hasn’t stopped firms from promoting DNA methylation testing kits to the general public.) They value about $300.

Should you resolve to get one in every of these assessments, have in mind your outcomes received’t provide you with a whole image of your well being and longevity. Getting older sometimes happens at various charges all through the physique. Your liver would possibly age quicker than your coronary heart or mind, for instance. So when you measure DNA methylation in your blood, that’s all you realize about. Put one other method, a DNA methylation check isn’t an alternative choice to your annual wellness checkup or blood work.

Business check #2: Telomere evaluation Telomeres—the protecting caps on the ends of chromosomes—put on away with age. The size of a telomere can predict what number of occasions a particular cell can divide earlier than dying.

Abnormally quick telomeres are related to a number of genetic ailments. For that reason, when physicians suspect somebody might need inherited a genetic illness, they’ll order a particular kind of telomere check—the flow-FISH check—to measure the telomere size in all of the cells in a blood pattern.22 23

It’s extra debatable whether or not telomere assessments can predict getting older in wholesome individuals.

Simply as importantly, the telomere check marketed to the general public, often known as the qPCR telomere check, isn’t utilized in analysis or drugs. These $100 assessments are advantageous when you’re merely curious—simply don’t base well being and health selections in your outcomes.

Business check #3: VO2 Max For years, solely elite athletes cared about VO2 max, which describes the utmost quantity of oxygen that your physique can use throughout train.

Extra just lately, nevertheless, some consultants have steered that VO2 max can function a measure for athletes and non-athletes alike to trace the speed at which their our bodies are getting older.

Individuals with excessive VO2 max have a tendency not solely to be extra bodily match but in addition much less more likely to develop coronary heart illness, diabetes, most cancers, or stroke.24 25 26 27

In an observational research that adopted the well being outcomes of 5,107 Danish males over 46 years, males with above-average V02 max throughout center age lived a mean of 5 years longer than males with below-average V02 max. Every unit enhance in VO2 max was related to a 45-day enhance in longevity. The researchers steered VO2 max might extra precisely predict all-cause mortality than excessive ldl cholesterol, weight problems, hypertension, and insulin resistance.28

You would possibly consider V02 max as a canary and your getting older physique as a coal mine.

As you age, your chest wall turns into extra inflexible, the muscle groups that encompass the lungs weaker, and the oxygen-carrying blood vessels calcified and fewer elastic. The guts additionally squeezes with much less drive, max coronary heart fee drops, muscle mass and energy decline, the mitochondria in cells and muscle groups lose their effectiveness, amongst different variations.

Along with elevating your threat for a lot of totally different ailments, these adjustments may also have an effect on VO2 max, which tends to say no 10 % per decade beginning round age 30.29 30

Up to now, the one approach to reliably measure VO2 max was in a health lab.

You'll put on a metabolic masks and a coronary heart monitor whilst you ran or cycled to exhaustion. The masks collected your expired carbon dioxide and monitored how a lot oxygen you sucked into your lungs. This lab-based testing remains to be probably the most correct approach to measure V02 max in addition to different key health metrics corresponding to:

Max coronary heart fee, or the very best variety of occasions your coronary heart can beat per minute throughout train Ventilatory threshold 1, or the purpose throughout train when the physique switches from primarily utilizing fats for gasoline to utilizing a mixture of fats and glucose or glycogen (saved glucose) for gasoline. Ventilatory threshold 2, or the purpose the place your physique strikes away from cardio metabolism (which makes use of oxygen) to anaerobic metabolism (which doesn’t use oxygen). Tidal quantity is the quantity of air inhaled or exhaled throughout every breath

Relying on the place you reside, you would possibly have the ability to get your VO2 max examined for round $150.

Nonetheless, when you don’t have entry to a VO2 max clinic, three considerably much less correct choices exist.

▶ The 1-mile stroll check

Put on a coronary heart fee monitor as you stroll one mile on a flat floor, corresponding to a treadmill or working observe. As quickly as you full the mile, document your coronary heart fee and stroll time. Then, plug it into the next formulation to calculate your VO2 max:

132.853 — (0.0769 × Weight) — (0.3877 × Age) + (6.315 × Intercourse) — (3.2649 × Time) — (0.1565 × Coronary heart fee)

If that seems like an excessive amount of math, you may also use a free on-line software.

▶ The smartwatch check

Many smartwatches will estimate your VO2 Max for you primarily based on info the watch gathers out of your exercises, intercourse, and age. In comparison with in-office testing, good watches can over- or underestimate V02 max, particularly in people who find themselves very off form or extraordinarily match.31

Due to this, you don’t essentially wish to use your good watch measurement to find out your present state of well being. Nonetheless, it could possibly provide help to to see traits. For instance, does your VO2 estimate drop after a couple of weeks of skipping your typical spin class? In that case, that’s good info to have.

▶ The PR check

Health efficiency correlates with longevity. Should you’re getting quicker at working a sure distance or can go an extended distance than earlier than, you’re getting fitter and rising your possibilities of dwelling an extended, wholesome life.

One approach to check this: the 12-minute run check, often known as the Cooper check. (This can be a validated approach to estimate VO2 max—and exhibits a few 90 % correlation with lab-based measurements.)

Right here’s the way it works:

Run as quick as you may on a flat floor, corresponding to a treadmill set at a 1 % incline or working observe, for 12 minutes. After 12 minutes, document your distance. Then, plug it into one of many following formulation to calculate your VO2 max.

Distance in Miles Distance in Kilometers

VO2 Max = (35.97 x distance in miles) – 11.29 (22.351 x distance in kilometers) – 11.288

In lieu of doing math, you may also use a free on-line calculator.

The way to change your organic age Attempt to think about the data you collect about your physique as simply that—info.

It’s not an ethical judgment of who you're as an individual.

Simply as importantly, it’s not a everlasting state of affairs.

Should you’re weaker than different individuals your age, you may develop stronger. In case your ldl cholesterol or blood glucose ranges are excessive, you may take steps to decrease them. In case your physique is getting older quicker than your birthdays, contemplate exploring key way of life adjustments that will assist flip the state of affairs round.

You have got choices. Nonetheless, most individuals make two massive errors relating to longevity-related way of life adjustments.

Mistake #1: Ignoring evergreen, big-impact methods It’s the easy, boring, “I’ve heard this one million occasions earlier than” well being practices that, when completed persistently, add as much as an extended, wholesome life.

We’re speaking about issues like…

Consuming extra minimally processed meals and fewer ultra-processed meals Consuming extra brightly coloured fruits and veggies Shifting your physique usually Getting sufficient relaxation and sleep Having fun with group, time in nature, and different actions that make life significant Protecting alcohol consumption reasonable Not utilizing tobacco Sporting sunscreen Flossing

And that’s only a partial record.

In accordance with hundreds of research, individuals who follow these and different high-impact methods not solely dwell longer, but in addition dwell higher. They’re stronger, happier, and fewer more likely to spend their later years disabled or in ache.

(Should you’d prefer to see the place you stand relating to massive impression well being and longevity methods, try our FREE Longevity Evaluation.)

Nonetheless, relating to well being, health, and longevity, many individuals pursue choices with minimal impression (at greatest). They attain for the newest, fashionable complement somewhat than taking steps to give up smoking, as only one instance.

Right here’s the factor: Huge rock methods require adjustments in habits. If every day bodily exercise have been as simple as popping a capsule, walkers and cyclists would clog up the streets in your neighborhood.

(It’s exactly this purpose why so many individuals want the assist of a licensed well being coach who has undergone coaching within the science of habits change.)

Mistake #2: Not turning information into motion The info gathered from biomarker getting older assessments may give you a way of management.

Nonetheless…

Information, in isolation, doesn’t result in an extended life.

Gathering information with out altering your habits is like checking your reflection within the mirror, seeing spinach wedged between your incisors, and leaving it there.

It's worthwhile to take away the spinach for the mirror test to be worthwhile.

Biomarker testing is identical.

Should you don’t use your bio information to tell habits change, you’re losing your time and cash.

Take into account your biomarker information as a baseline or place to begin.

Then, use it to evaluate whether or not varied way of life adjustments or medical interventions are shifting you nearer to your objective of dwelling an extended, more healthy life.

References Click on right here to view the data sources referenced on this article.

1. Grind Ok. How Bryan Johnson, Who Needs to Reside Without end, Sought Management through Confidentiality Agreements. The New York Instances [Internet]. 2025 Mar 21 [cited 2025 Jul 15]; Accessible from: https://www.nytimes.com/2025/03/21/know-how/bryan-johnson-blueprint-confidentiality-agreements.html

2. Strasser B, Volaklis Ok, Fuchs D, Burtscher M. Position of dietary protein and muscular health on longevity and getting older. Getting older Dis. 2018 Feb 1;9(1):119–32.

3. Araujo CG, de Souza E Silva CG, Laukkanen JA, Fiatarone Singh M, Kunutsor SK, Myers J, et al. Profitable 10-second one-legged stance efficiency predicts survival in middle-aged and older people. Br J Sports activities Med. 2022 Sep 1;56(17):975–80.

4. Araújo CGS, de Souza e Silva CG, Myers J, Laukkanen JA, Ramos PS, Ricardo DR. Sitting–rising check scores predict pure and cardiovascular causes of deaths in middle-aged and older women and men. Eur J Prev Cardiol. 2025 Jun 18;zwaf325.

5. Dodds RM, Kuh D, Sayer AA, Cooper R. Can measures of bodily efficiency in mid-life enhance the medical prediction of incapacity in early outdated age? Findings from a British beginning cohort research. Exp Gerontol. 2018 Sep;110:118–24.

6. Bohannon RW. Grip energy: An indispensable biomarker for older adults. Clin Interv Getting older. 2019 Oct 1;14:1681–91.

7. Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, et al. Prognostic worth of grip energy: findings from the Potential City Rural Epidemiology (PURE) research. Lancet. 2015 Jul 18;386(9990):266–73.

8. Rezaei A, Bhat SG, Cheng C-H, Pignolo RJ, Lu L, Kaufman KR. Age-related adjustments in gait, steadiness, and energy parameters: A cross-sectional research. PLoS One. 2024 Oct 23;19(10):e0310764.

9. Corridor KS, Cohen HJ, Pieper CF, Fillenbaum GG, Kraus WE, Huffman KM, et al. Bodily efficiency throughout the grownup life span: Correlates with age and bodily exercise. J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):572–8.

10. Glynn NW, Gmelin T, Renner SW, Qiao YS, Boudreau RM, Feitosa MF, et al. Perceived bodily fatigability predicts all-cause mortality in older adults. J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):837–41.

11. Simonsick EM, Schrack JA, Santanasto AJ, Studenski SA, Ferrucci L, Glynn NW. Pittsburgh Fatigability Scale: One-page predictor of mobility decline in mobility-intact older adults. J Am Geriatr Soc. 2018 Nov 1;66(11):2092–6.

12. Vercelli S, Zampogna E, Negrini F, Pietraroia C, D’Antona G, Papa S, et al. Cross-cultural translation, validation, and responsiveness of the Pittsburgh Fatigability Scale – Italian model (PFS-I) in a mixed-sample of older adults. BMC Geriatr. 2024 Dec 19;24(1):1016.

13. Combest TM, Khan J, Tufano JJ, Lane M, Watson NL, Altom KR, et al. Comparability of 4 physique composition strategies: Circumference measurements, eight-point bioelectrical impedance evaluation as much as 500 and 1000 kHz to dual-energy X-ray absorptiometry to measure physique fats share. Mil Med [Internet]. 2024 Sep 18 [cited 2025 Jan 11]

14. Dayer SR, Mears SC, Pangle AK, Mendiratta P, Wei JY, Azhar G. Does superior bone well being promote an extended lifespan? Geriatr Orthop Surg Rehabil. 2021 Aug 3;12:21514593211036231.

15. Mera P, Laue Ok, Wei J, Berger JM, Karsenty G. Osteocalcin is critical and adequate to keep up muscle mass in older mice. Mol Metab. 2016 Oct 1;5(10):1042–7.

16. Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, et al. Identification of osteoclast-osteoblast coupling components in people reveals hyperlinks between bone and vitality metabolism. Nat Commun. 2020 Jan 7;11(1):87.

17. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of vitality metabolism by the skeleton. Cell. 2007 Aug 10;130(3):456–69.

18. Tran T, Bliuc D, Hansen L, Abrahamsen B, van den Bergh J, Eisman JA, et al. Persistence of extra mortality following particular person nonhip fractures: A relative survival evaluation. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3205–14.

19. Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai P-C, et al. DNA methylation-based measures of organic age: meta-analysis predicting time to demise. Getting older (Albany NY). 2016 Sep 28;8(9):1844–65.

20. Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj Ok, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Getting older (Albany NY). 2019 Jan 21;11(2):303–27.

21. Belsky DW, Caspi A, Corcoran DL, Sugden Ok, Poulton R, Arseneault L, et al. DunedinPACE, a DNA methylation biomarker of the tempo of getting older. Elife. 2022 Jan 14;11:e73420

22. Alder JK, Hanumanthu VS, Robust MA, DeZern AE, Stanley SE, Takemoto CM, et al. Diagnostic utility of telomere size testing in a hospital-based setting. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2358–65.

23. Vaiserman A, Krasnienkov D. Telomere size as a marker of organic age: State-of-the-art, open points, and future views. Entrance Genet. 2020;11:630186.

24. Imboden MT, Harber MP, Whaley MH, Finch WH, Bishop DL, Kaminsky LA. Cardiorespiratory health and mortality in wholesome women and men. J Am Coll Cardiol. 2018 Nov 6;72(19):2283–92.

25. Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, et al. Causal associations between cardiorespiratory health and sort 2 diabetes. Nat Commun. 2023 Jul 3;14(1):3904.

26. Aker A, Saliba W, Bahouth F, Naoum I, Zafrir B. Cardiorespiratory health and threat of cardiovascular occasions and mortality in center age sufferers with out recognized heart problems. J Clin Med. 2023 Nov 9;12(22):7011.

27. Prestgaard E, Mariampillai J, Engeseth Ok, Erikssen J, Bodegård J, Liestøl Ok, et al. Change in cardiorespiratory health and threat of stroke and demise: Lengthy-term follow-up of wholesome middle-aged males: Lengthy-term follow-up of wholesome middle-aged males. Stroke. 2019 Jan;50(1):155–61.

28. Clausen JSR, Marott JL, Holtermann A, Gyntelberg F, Jensen MT. Midlife cardiorespiratory health and the long-term threat of mortality: 46 years of follow-up. J Am Coll Cardiol. 2018 Aug 28;72(9):987–95.

29. Kim C-H, Wheatley CM, Behnia M, Johnson BD. The impact of getting older on relationships between lean physique mass and VO2max in rowers. PLoS One. 2016 Aug 1;11(8):e0160275.

30. Strasser B, Burtscher M. Survival of the fittest: VO2max, a key predictor of longevity? Entrance Biosci (Landmark Ed). 2018 Mar 1;23(8):1505–16.

31. Caserman P, Yum S, Göbel S, Reif A, Matura S. Assessing the accuracy of smartwatch-based estimation of most oxygen uptake utilizing the Apple Watch Sequence 7: Validation research. JMIR Biomed Eng. 2024 Jul 31;9(1):e59459.

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