The Crucial Connection Between Vitamin K2, Calcium Metabolism, and Disease Prevention

[ad_1] For many years, the standard recommendation for optimum bone well being has been to take calcium dietary supplements — however the reality is that with out the proper co-factors, like vitamin K2, this nutrient does not find yourself strengthening bones, and will trigger harm as an alternative.

Vitamin K2 ensures that calcium binds to bone the place it belongs. With out ample quantities of K2, calcium builds up in locations the place it should not — like your arteries — whereas leaving your bones weak and brittle. That is why folks with low vitamin K2 ranges typically develop each osteoporosis and hardened arteries, a paradox that drastically will increase their danger of fractures and coronary heart illness.

Vitamin K2 Strengthens Bones and Protects Towards Fractures A evaluation revealed in Vitamins examined the position of vitamin K2 in bone well being, particularly its impression on bone mineral density (BMD) and fracture danger in adults. The researchers centered on how K2 influences calcium utilization within the physique, making certain that this important mineral strengthens bones slightly than accumulating in arteries. 1

• Vitamin K2 strengthens skeletal operate — The research analyzed a inhabitants of older adults, who're significantly weak to bone loss and fractures. They discovered that members who often consumed vitamin K2, whether or not by eating regimen or supplementation, exhibited stronger bones and a decrease danger of fractures in comparison with these with decrease consumption ranges.

The researchers famous that K2 supplementation was particularly helpful for postmenopausal ladies, who're on the highest danger for osteoporosis-related fractures.

• Bone mineral density is increased — One of the crucial placing findings was the measurable enhance in BMD amongst these supplementing with K2. Bone density improved considerably inside months, decreasing the probability of fractures over time. People with low K2 consumption had indicators of weakened bone construction, making them extra inclined to breaks from minor falls or accidents.

• Threat of fractures is lowered — The research additionally checked out fracture charges over time. Contributors with increased K2 consumption had fewer fractures, significantly within the hip and backbone, two of essentially the most weak areas in ageing people.

The distinction was important — these with inadequate K2 consumption skilled practically twice as many fractures as those that maintained enough ranges. This implies that K2 not solely improves bone density but in addition enhances bone energy and resilience.

• Vitamin K2 directs calcium — The organic mechanism behind these findings is simple however highly effective. Vitamin K2 prompts key proteins — osteocalcin and matrix Gla protein (MGP) — which direct calcium the place it's wanted and stop it from accumulating the place it should not.

Osteocalcin ensures calcium binds to the bone matrix, whereas MGP prevents calcium deposits from forming in arteries. With out ample K2, these proteins stay inactive, resulting in each weakened bones and arterial calcification.

• Vitamin D interplays with vitamin K2 — To summarize, the researchers stated, "[W]e discover that an enough provide of vitamin Okay, on prime of an optimum vitamin D standing, appears so as to add to the good thing about sustaining bone well being. Extra analysis associated to synergism and the attainable mechanisms of nutritional vitamins D3 and Okay interplay in bone well being is required." 2

Issues and Challenges Concerning Vitamin K2 Absorption Nonetheless, there are important challenges in terms of optimizing vitamin K2. For instance, testing is not extensively accessible, as most docs don't think about it a part of routine well being screenings. There are additionally particular person components that have an effect on your skill to make the most of K2, certainly one of which is your genetics.

• The journey to testing vitamin K2 — Within the video above, Nadir Shah, a licensed structural engineer and academic guide who runs the YouTube channel "Data for High quality of Life," shares his private well being journey and the way he found that your genetic make-up influences the quantity of vitamin K2 you soak up.

His analysis started again in 2021, when he and his spouse (who has osteopenia, or bone density loss) turned curious if they're assembly the optimum ranges of vitamins — significantly for vitamin K2. 3

• Vitamin K2 testing is difficult — In keeping with Shah, "There isn't any such check that which might check all of the micronutrients and all of the nutritional vitamins, all of the minerals, as a result of I have been looking these assessments, principally within the insurance coverage literature, medical health insurance, which I am coated with, and there is none principally.

We have been taking vitamin K2 together with vitamin D, which I've talked about in my earlier vlogs. We have been taking 100 micrograms, myself and my spouse, each. We have been taking the identical dosage. However there is no such thing as a check for vitamin K2," Shah defined. 4

After an in depth search, Shah was capable of finding two labs that provided testing for K2 — Genova Diagnostic and Vibrant Labs of America. Nonetheless, there is no such thing as a separate K2 check; it is truly a part of a micronutrient panel check that prices practically $400. What's extra, the check must be prescribed by a doctor. 5

• Discovering an answer — In keeping with Shah, he discovered an integrative drugs physician in Phoenix, Arizona who advocate Vibrant Labs of America for micronutrient panel testing. After this encounter, his household received their outcomes after 4 to 6 weeks.

• The significance of getting examined — Shah famous that, "[T]he eye-opening factor for me in that check … was the vitamin K2 stage. I got here OK in vitamin K2, however my spouse was a bit brief. She was OK on the serum stage, after I say serum stage means it is the blood stage, however on the blood cells on the mobile stage, she falls brief. And that was an alarming level for me …"

As Shah and his spouse had been taking the identical dose, he then sought solutions as to why there was such a big distinction of their ranges. Her mobile ranges of this nutrient weren't reaching the optimum quantity, which implies it is not activating the vitamin Okay-dependent proteins, matrix Gla protein and osteocalcin. It took him months, however he ultimately discovered the reply in a analysis paper. 6

The Function of ApoE Genotype in Vitamin K2 Absorption Your apolipoprotein E (ApoE) genotype is among the key genetic markers concerned in processing vitamin K2. This gene influences how your physique processes fat and nutritional vitamins, together with vitamin K2. There are completely different variations of the ApoE gene, and relying on which one you inherit, your physique could both clear vitamin K2 shortly or retain it for an extended time. In Shah's case, he and his spouse have completely different ApoE genotypes. 7

• The variations in genotypes — In keeping with Shah, "There are genotypes which we now have inherited from mother and pa. There are principally three copies: 2, 3, and 4. Then there's a combo 2/3, 3/3, 3/4, and 4/4. So, there is a mixture of six altogether. These are referred to as ApoE genotype alleles."

• Genotypes decide vitamin K2 clearing — Shah continues, "I discovered in that paper that people who find themselves ApoE 2/2, they clear vitamin K2 very sluggish; significantly, their clearance price may be very sluggish. Now, 3/3 are usually neither sluggish nor quick, however 3/4 and 4/4 folks — individuals who carry ApoE one copy of 4 or double copy of 4 — they clear their vitamin K2 from the physique fairly quick.

It signifies that the dosage which I have been taking, 100 micrograms … was okay as a result of I am 3/3. We received each examined after that and that was like a light-weight bulb went on," Shah says. 8

Many individuals have no idea their ApoE genotype as a result of it's not a normal diagnostic check. Nonetheless, getting examined supplies priceless insights into how your physique processes vitamin K2 and different vitamins. After studying this data, Shah elevated his spouse's K2 dose, and since then they've seen noticeable outcomes.

• The impression of accelerating vitamin K2 consumption — Shah recollects their story, "Since 2021, we did one other DEXA scan. Her osteopenia stopped progressing at two areas. That is a great signal. Excellent signal. As a result of if … the T-score does not go within the unfavourable additional, it signifies that it has stopped. It signifies that she is getting sufficient K2 …"

• Boosting your vitamin K2 consumption has no uncomfortable side effects — In keeping with Shah, his spouse is "consuming natto as nicely. She is within the vary of in all probability 800, 900 micrograms — eight- or ninefold than what she was taking earlier than. And I'm the identical method. I elevated regardless that I used to be okay, however I elevated as a result of there is no such thing as a, we do not really feel any facet impact, nothing in any respect." 9

He provides that understanding your ApoE genotype can also be helpful for different points of your well being. Sure variations are linked to the next danger of Alzheimer's illness, cardiovascular points, and the way your physique handles ldl cholesterol. Understanding this data will make it easier to make higher selections about your eating regimen, dietary supplements, and total way of life.

The Sort of Vitamin K2 You Take Issues Shah additionally mentions that the type of vitamin K2 impacts how effectively you soak up it. The most typical types are menaquinone-4 (MK-4) and menaquinone-7 (MK-7).

• The distinction between MK-4 and MK-7 — Shah explains, "MK-4's half-life is just 4 hours and MK-7's half-life is 72 hours. It stays within the system within the physique longer … So, it signifies that MK-7 is just not good for people who find themselves ApoE genotype 2/2, as a result of I have been seeing lots of people once they take K2 MK-7, they really feel palpitation.

What occurs is that, based mostly on the literature, in the event that they take [it] on every day foundation, the physique is just not clearing as a result of it is clearing sluggish, it may again up after which it may offer you a facet impact."

• Your genotype dictates which type of vitamin Okay is best — From Shah's findings, he famous that "People who find themselves ApoE genotype 2/2, based mostly on the literature, they're higher off with MK-4 as a result of it clears quick. Now, if you're 2/2 — the one method we're going to know what kind of ApoE genotype we feature is we have to get examined, and it is a as soon as in a lifetime check." 10

• Prime sources of MK-4 — MK-4 is a short-chain type of vitamin K2 present in animal merchandise similar to meat, eggs, liver, and dairy. 11 , 12 Nonetheless, it has a brief organic half-life, which makes it a poor candidate as a dietary complement. Nonetheless, MK-4 from meals is vital for good well being because it performs a job in gene expression. For instance, analysis has discovered it helps decrease your danger of liver most cancers. 13

• Prime sources of MK-7 — In the meantime, MK-7 is a longer-chained vitamin K2 present in fermented meals similar to sauerkraut, sure cheeses, and natto. It is produced by particular micro organism through the fermentation course of. Nonetheless, not all strains of micro organism make it, so not all fermented meals will present it. 14

Make Positive Calcium Goes to the Proper Locations If you need robust bones and versatile arteries, getting sufficient vitamin K2 is non-negotiable. With out it, calcium results in all of the unsuitable locations — clogging your arteries as an alternative of strengthening your bones. The excellent news is, you've gotten management over this. By making a couple of easy changes, the calcium you ingest will give you the results you want, not towards you.

1. Get sufficient vitamin K2 from the proper sources — Your physique wants K2 to activate the proteins that direct calcium into your bones and preserve it out of your arteries. The perfect pure sources are natto, onerous cheeses like Gouda, egg yolks, and organ meats.

In case you do not often eat these meals, think about a high-quality vitamin K2 complement. In case you go for an oral K2 complement, it is best taken along with your night meal, together with any vitamin D and/or calcium and magnesium you take.

2. Steadiness your nutritional vitamins D3 and K2 consumption — In case you are supplementing with calcium and vitamin D3 however not vitamin K2, you are making an enormous mistake. Vitamin D3 will increase calcium absorption, however, as mentioned, you want K2 to forestall that additional calcium from going the place it does not belong.

At all times make it possible for for each 5,000 IUs of vitamin D3 you're taking, you are additionally getting round 180 micrograms (mcg) of vitamin K2. This retains calcium metabolism in steadiness and prevents calcification the place you don't need it.

3. Get rid of vegetable oils and processed meals — An excessive amount of linoleic acid (LA), present in vegetable oils like soybean, canola, and corn oil, damages your arteries, making them extra weak to calcium buildup.

Processed meals are full of these inflammatory oils, so eliminating them out of your eating regimen is among the finest methods to help your coronary heart and total well being. As an alternative, prepare dinner with saturated fat like grass fed butter, ghee, or tallow, and keep away from something that lists vegetable oil as an ingredient.

4. Get extra magnesium to maintain calcium in test — Together with vitamin K2, magnesium is one other key to correct calcium regulation. It helps stop calcium from accumulating in tender tissues. In case you're not getting sufficient magnesium, your physique struggles to correctly use each nutritional vitamins K2 and D3.

The simplest approach to discover your very best magnesium dose is through the use of magnesium citrate — slowly growing the quantity till you discover unfastened stools, then backing off barely. As soon as you understand your threshold, you may swap to different types of magnesium, similar to magnesium threonate (which does not trigger unfastened stools), for higher mind and bone advantages.

In case you're consuming a balanced eating regimen with dairy, leafy greens, and bone broth, you in all probability do not want additional calcium. As an alternative, concentrate on getting the proper co-factors talked about above, and let your physique deal with the remainder naturally.

Often Requested Questions on Vitamin K2 and Bone Well being Q: Why is vitamin K2 vital for bone well being?

A: Vitamin K2 performs an important position in directing calcium to the bones, the place it strengthens bone mineral density (BMD) and reduces fracture danger. With out ample K2, calcium accumulates in arteries as an alternative, growing the chance of each osteoporosis and heart problems.

Q: How does vitamin K2 impression bone density and fracture danger?

A: Research present that vitamin K2 supplementation improves BMD and considerably reduces fractures, particularly in older adults and postmenopausal ladies. It prompts osteocalcin and matrix Gla protein (MGP), which guarantee calcium binds to bones slightly than accumulating in arteries.

Q: What components have an effect on vitamin K2 absorption within the physique?

A: Genetics, particularly the ApoE genotype, affect how shortly your physique clears vitamin K2. People with ApoE 3/4 or 4/4 genotypes clear K2 sooner and can want increased doses, whereas these with ApoE 2/2 clear it slowly and are higher suited to the MK-4 type of vitamin K2.

Q: What are the very best sources of vitamin K2?

A: Pure sources of vitamin K2 embody fermented meals like natto, cheese constituted of grass fed dairy, egg yolks, and organ meats. For supplementation, MK-4 has a shorter half-life and is best suited to quick K2 metabolizers, whereas MK-7 stays within the physique longer and is preferable for slower metabolizers.

Q: How can I guarantee calcium is used correctly in my physique?

A: To direct calcium to bones and stop arterial calcification, preserve a steadiness of nutritional vitamins K2, D3, and magnesium. Purpose for 180 mcg of vitamin K2 for each 5,000 IUs of D3. Additionally, keep away from processed meals and vegetable oils, which contribute to arterial harm and improper calcium distribution.